Anti-Aging







EPITALON PEPTIDE



What do you think can be done today to stop aging or its devastating effects ?

You probably think of rubbing lotion on your face, eating antioxidant food and supplements, doing brain exercises to keep it agile, and physical activities to stay fit?

Let us present you something that will really surprise you and that is available today: Literally keeping your body young or make it younger, down to the cellular level !

A quite recent scientific discovery allows us to influence the genetic clock. The very mechanism by which our body ages has been exposed, and we’ve found the way to reverse it.

It’s the most important breakthrough in the history of medicine and anti-aging care. It is so powerful that it changes people’s life in a way than no one could achieve before, right from the first days of taking it.

And you can’t find it anywhere else, as it was not available to individuals buyers until today.

The amazing power of this breakthrough lies in a genetic structure called the telomeres. It’s the elements that control the aging of our cells.

Telomeres.





What are the telomeres? They’re the protective ends of our DNA strings:

It is known that telomeres protect your DNA, and that when they become too short, the cells can’t multiply anymore.

Telomeres are considered as our biological clock, and each time our cells divide, and the DNA replicates itself, the telomeres get shorter and shorter until the cells stop dividing and die, and ultimately the entire body is enable to regenerate itself and it dies too.


This process happens slowly, and it’s called aging.

Fortunately, science found a molecule that activates the regeneration of the telomeres, lengthening them again, allowing your cells to duplicate ever and ever again, rebuilding your body anew, repairing your damaged DNA, and reconstructing your organs to their original design.

In 1999, Elisabeth Blackburn was Laureate of the Nobel Prize for discovering the telomere activator enzyme named telomerase. Telomerase rebuilds the end of the telomeres to their original length after each cell division, halting the biological death-clock.


But telomerase is less and less generated in the cells, as years go by, and that’s why telomeres are not restored and become shorter and shorter.

What I am presenting you today is the discovery of a peptide and enzyme Epitalon together with nano gold that will reactivate the production of telomerase in the cells, allowing the reparation of the telomeres, and resulting in the rejuvenation of the body, right down to the genetic cellular level.

This simple tetrapeptide Epitalon together with nano gold simulates the effect of a secretion from the pineal gland, that activates the production of telomerase in the cells. Several studies have proven that the length of the telomeres increase after taking Epitalon orally, and that the humans taking it live longer than those who don’t take it.

After 12 years of only taking the peptide Epitalon several weeks per year, the scientists subjects in this study, showed a lifespan 30 to 50% longer than those who didn’t take it. This clinical study lasted only for 12 years, and they gained extra years of life, but of course, nothing stops you from taking Epitalon forever, and live healthy for ... EVER !

Rejuvenated cells are also the key to an efficient immune system. For that reason, taking Epitalon will also keep your body fit against many diseases.

This amazing oral supplement is taken by numerous doctors around the world, and a few privileged patients that consult them. Now you can have it too !

We have decided to enlarge the circle of the privileged humans that will be able to prolong their lives without limits, by offering Epitalon in its purest form and for a much lower price than it was available today through medical professionals. We bring now this product to the public market, as it was only available to medical professionals until today.

To guaranty the quality of the product and its distribution service, we have unfortunately limited the number of units that we will offer during the first phase of commercialization.

We are offering only vials of pure Epitalon for people who only have economical capacitity. Yes, it’s very little compared to the population of the world, but we hope that one day every good person will have the chance to live longer with pure Epitalon. And here below you can read some information we putted about the scientific facts of Telomeres and testings with the peptide and enzyme Epitalon.

We hope sincerely that you will be part of the lucky ones that can buy the pure Epitalon.

Activators of telomerase hit the market!

Medicine is changing by leaps and bounds and activators of telomerase play a strategic role in this progress for reversing the aging process. This peptide is a small molecule produced in our pineal gland, a small gland located behind and to the base of the brain which is also where melatonin is produced, the sleep hormone.

The daily injection of the peptide and enzyme for ten days every six months, to the elderly, namely the older members of the eminent Russian Academy of Sciences, has enabled many of them to increase their longevity. Mortality in this assembly was reduced by 30 to 50% over seven years in those who took it. The peptide and enzyme is only accessible to experts and to those who go in consultation with the Institute of Gerontology of the Academy of Sciences in St. Petersburg.

We were excited by this statement, which spoke of a scientific study that showed a considerable increase (30 to 50%) of the lives of its participants, as well as the correction of presbyopia with injections!
So we started looking for any scientific information available on this product announced as having effects that we describe as miraculous!

Make our body immortal
The Epitalon regulates cell function by triggering the production of telomerase, which will repair the telomeres, allowing the cells to become young again and to produce other cells.

Long telomeres will also help correct errors in DNA during cell division and prevent cellular degeneration.

This peptide together with the nanogold trigger the rejuvenation of the whole body, from internal organs to the skin. It is the fountain of youth !

Telomeres act as a biological clock governing the life of cells. Telomeres shorten progressively with each cell division until the cell can no longer divide and dies.

When the telomere becomes too short, it no longer plays a protective role. The cell will interpret this as a corruption of its DNA, enter senescence and stop its growth. Organs deteriorate even more than their constituent cells die or come into senescence.

" Diseases of aging reversed in mice"

The study was published online Sunday in the journal Nature.

"These mice had an age equivalent to 80 years in men, and were about to die," said Ronald DePinho, co-author of the study and researcher at the Dana-Farber Cancer Institute in Boston. After the experiment, "they were back to the physiological equivalent of young adults."

The experiment focused on telomerase, an enzyme that makes the units of DNA that seal the ends of chromosomes, called telomeres.


What is Epitalon?

The Epitalon compound is a small peptide of 5 amino acids.

Scientific studies show that telomeres lengthen with only taking of peptide Epitalon. The cell's biological clock is reset, the cell regains its integrity and can start to multiply to repair the body's immune system to operate and maintain organs at their optimal level, and continue the growth of the body.

Daily intake of the peptide by the elderly, namely the older members of the eminent Russian Academy of Sciences, has enabled many of them to increase their longevity. Mortality in this assembly was reduced by 30 to 50% over seven years in those who took it.

To this day the peptide and enzyme was only available for research and medical centers. Especially because several patents have been filed by Professor Khavison, in USA, Europe and Asia.


After Telomerase Activation They Live 24% Longer!
Article pulished in The EMBO Scientific Publications;
full article for free here.



RESULTS: Based on this notion, we tested the effects of a telomerase gene therapy in adult (1 year of age) and old (2 years of age) mice. Treatment of both groups of mice with an AAV of wide tropism expressing mouse telomerase (mTERT) demonstrated remarkable beneficial effects on health and fitness, improving several molecular biomarkers of aging. Moreover, telomerase-treated mice did not develop more neoplasias comparing to their control littermates, suggesting that the known tumorigenic activity of telomerase is severely decreased when expressed in adult or old organisms. Finally, re-introduction of mTERT in both 1- and 2-year old mice increased significantly its median lifespan (24 and 13%, respectively).


These beneficial effects were not observed with a reporter virus (eGFP) or a catalytically inactive TERT (TERT-DN) demonstrating the strict dependency of an active telomerase complex.

The rate of increase of short telomeres predicts longevity in mammals.

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Center, Melchor Fernández Almagro 3, E-28029 Madrid, Spain.

Abstract: Aberrantly short telomeres result in decreased longevity in both humans and mice with defective telomere maintenance. Normal populations of humans and mice present high interindividual variation in telomere length, but it is unknown whether this is associated with their lifespan potential. To address this issue, we performed a longitudinal telomere length study along the lifespan of wild-type and transgenic telomerase reverse transcriptase mice. We found that mouse telomeres shorten ~100 times faster than human telomeres. Importantly, the rate of increase in the percentage of short telomeres, rather than the rate of telomere shortening per month, was a significant predictor of lifespan in both mouse cohorts, and those individuals who showed a higher rate of increase in the percentage of short telomeres were also the ones with a shorter lifespan. These findings demonstrate that short telomeres have a direct impact on longevity in mammals, and they highlight the importance of performing longitudinal telomere studies to predict longevity.
Published by Elsevier Inc.

Partial reversal of aging achieved in mice.
Control of telomerase gene appears to control process


In a report posted online by the journal Nature in advance of print publication, researchers led by Ronald A. DePinho, a Harvard Medical School (HMS) professor of genetics, said they achieved the milestone in aging science by engineering mice with a controllable telomerase gene. The telomerase enzyme maintains the protective caps called telomeres that shield the ends of chromosomes.


Aging Ills Reversed in Mice

Scientists Tweak a Gene and Rejuvenate Cells, Raising Hopes for Uses in Humans

Scientists have partially reversed age-related degeneration in mice, an achievement that suggests a new approach for tackling similar disorders in people.
By tweaking a gene, the researchers reversed brain disease and restored the sense of smell and fertility in prematurely aged mice. Previous experiments with calorie restriction and other methods have shown that aspects of aging can be slowed. This appears to be the first time that some age-related problems in animals have actually been reversed.




Dana-Farber Cancer Institute, Two mice involved in an experiment on age-related degeneration. Mice whose telomerase gene was activated showed notable improvements.

The study was published online Sunday in the peer-reviewed journal Nature. "These mice were equivalent to 80-year-old humans and were about to pass away," says Ronald DePinho, co-author of the paper and a scientist at Dana-Farber Cancer Institute in Boston. After the experiment, "they were the physiological equivalent of young adults."

The institute is a teaching affiliate of Harvard Medical School. The first author of the study is Mariela Jaskelioff at Dr. DePinho's lab.

Although the finding is compelling, it remains to be seen whether the approach can slow the signs and symptoms of aging in people. The latest results were obtained with mice that were specifically altered to age prematurely. And while the animals showed no signs of tumors, there is a risk that the technique could trigger cancer.

The experiment focused on telomerase, an enzyme that makes small units of DNA that seal the tips of chromosomes. These DNA units, known as telomeres, act like the plastic caps at the ends of a shoelace, preventing the chromosomes from fraying and the genes inside them from unraveling. In 2009, three U.S. scientists won the Nobel Prize in medicine for illuminating the mysteries of telomerase.

New Lease on Life

How scientists partly reversed age-related degeneration in mice

• Scientists engineered prematurely aged mice that developed age-related problems; testes produced little sperm, brains stopped producing new cells and sense of smell atrophied.

• They injected the mice with a drug that switched on a gene, which stimulated telomerase production. That lengthened the telomeres that cap the ends of chromosomes and keep them from fraying.

• In the treated mice, their testes produced new, viable sperm cells, their brains began producing new cells and their sense of smell returned.

• The treated animals went on to have a typical lifespan, though they didn't live longer than normal mice.

Many different stimuli conspire and contribute to the aging process. The telomere is just one of them and likely not the most dominant. In normal tissue, telomeres get progressively shorter as part of the aging process, causing cells to stop dividing. As a result, stem cells go into a state of quiescence, organs atrophy and brain cells die.

As people age, low levels of telomerase are linked to the erosion of telomeres. Dr. DePinho and his colleagues wanted to see if by reactivating telomerase in mice they could halt—or possibly reverse—the shortening of telomeres, and thus turn back the clock on some aspects of aging.

The team made genetically engineered mice that aged prematurely. The animals had short, dysfunctional telomeres and suffered a range of age-related problems. Their spleens were atrophied, their intestines were damaged, and the sense of smell was impaired.

The brains were also shrunken, and the animals were incapable of growing new brain cells. Male mice had smaller-than-normal testes and produced depleted amounts of sperm.

"We stacked the deck against us and asked: Is there a point of no return?" said Dr. DePinho.

The researchers had devised an estrogen-based drug that would switch on the animals' dormant telomerase gene, known as TERT. The drug, in the form of a time-release pellet, was inserted under the skin of some mice. A similar pellet without the active drug was given to a separate group of control mice.

A month later, the treated mice showed surprising signs of rejuvenation. Overall, their telomeres had lengthened and the levels of telomerase had increased. This woke up the dormant brain stem cells, producing new neurons. The spleen, testes and brain grew in size.




In addition, key organs started to function better. The treated mice regained their sense of smell. The male animals' once-depleted testes produced new sperm cells, and their mates gave birth to larger litters. The treated animals went on to have a typical lifespan, though they didn't live longer than normal mice.

The reversals of age-related decline seen in the animals "justify exploration of telomere rejuvenation strategies for age-associated diseases," the paper concludes.

One worry is cancer. Tumors somehow turn on the telomerase gene, allowing cancer cells to divide continuously. Up to 90% of human cancers require certain levels of telomerase to do so. Indeed, many researchers are trying to deactivate telomerase as a cancer-fighting strategy.

Still, turning on telomerase for controlled periods of time might be useful. The strategy might one day have a role in treating rare genetic disorders that are linked to telomeres and cause premature aging, such as Werner's syndrome, according to Dr. DePinho.

The telomerase technique may also be relevant for people who age normally—provided it is clear that prolonged telomerase reactivation doesn't trigger tumors in later life.

Statistically, people with longer telomeres in their blood cells have an increased number of healthy years beyond the age of 60, Dr. DePinho said. And those over 60 with the shortest telomeres have higher rates of diabetes, cardiovascular disease and Alzheimer's.

Dr. DePinho said the next step was to try the technique on normally aged mice to see whether it can slow, halt or reverse signs of aging in them.

Harvard scientists at Dana-Farber Cancer Institute say they have for the first time partially reversed age-related degeneration in mice, resulting in new growth of the brain and testes, improved fertility, and the return of a lost cognitive function. In a report posted online by the journal Nature in advance of print publication, researchers led by Ronald A. DePinho, a Harvard Medical School (HMS) professor of genetics, said they achieved the milestone in aging science by engineering mice with a controllable telomerase gene. The telomerase enzyme maintains the protective caps called telomeres that shield the ends of chromosomes.

As humans age, low levels of telomerase are associated with progressive erosion of telomeres, which may then contribute to tissue degeneration and functional decline in the elderly. By creating mice with a telomerase switch, the researchers were able to generate prematurely aged mice. The switch allowed the scientists to find out whether reactivating telomerase in the animals would restore telomeres and mitigate the signs and symptoms of aging. The work showed a dramatic reversal of many aspects of aging, including reversal of brain disease and infertility.

While human applications remain in the future, the strategy might one day be used to treat conditions such as rare genetic premature aging syndromes in which shortened telomeres play an important role, said DePinho, senior author of the report and the director of Dana-Farber’s Belfer Institute for Applied Cancer Science. “Whether this would impact on normal aging is a more difficult question,” he added. “But it is notable that telomere loss is associated with age-associated disorders and thus restoration of telomeres could alleviate such decline.” The first author is Mariela Jaskelioff, a research fellow in medicine in DePinho’s laboratory.

Importantly, the animals showed no signs of developing cancer. This remains a concern because cancer cells turn on telomerase to make themselves virtually immortal. DePinho said the risk can be minimized by switching on telomerase only for a matter of days or weeks — which may be brief enough to avoid fueling hidden cancers or cause new ones to develop. Still, he observed, it is an important issue for further study.

In addition, DePinho said these results may provide new avenues for regenerative medicine, because they suggest that quiescent adult stem cells in severely aged tissues remain viable and can be reactivated to repair tissue damage.

“If you can remove the underlying damage and stresses that drive the aging process and cause stem cells to go into growth arrest, you may be able to recruit them back into a regenerative response to rejuvenate tissues and maintain health in the aged,” he said. Those stresses include the shortening of telomeres over time that causes cells and tissues to fail.

Loss of telomeres sends a cascade of signals that cause cells to stop dividing or self-destruct, stem cells to go into retirement, organs to atrophy, and brain cells to die. Generally, the shortening of telomeres in normal tissues shows a steady decline, except in the case of cancer, where they are maintained.

The experiments used mice that had been engineered to develop severe DNA and tissue damage as a result of abnormal, premature aging. These animals had short, dysfunctional telomeres and suffered a variety of age-related afflictions that progressed in successive generations of mice. Among the conditions were testes reduced in size and depleted of sperm, atrophied spleens, damage to the intestines, and shrinkage of the brain along with an inability to grow new brain cells.

“We wanted to know: If you could flip the telomerase switch on and restore telomeres in animals with entrenched age-related disease, what would happen?” explained DePinho. “Would it slow down aging, stabilize it, or even reverse it?”

Rather than supply the rodents with supplemental telomerase, the scientists devised a way to switch on the animals’ own dormant telomerase gene, known as TERT. They engineered the endogenous TERT gene to encode a fusion protein of TERT and the estrogen receptor. This fusion protein would only become activated with a special form of estrogen. With this setup, scientists could give the mice an estrogen-like drug at any time to stimulate the TERT-estrogen receptor fusion protein and make it active to maintain telomeres.

Against this backdrop, the researchers administered the estrogen drug to some of the mice via a time-release pellet inserted under the skin. Other animals, the controls, were given a pellet containing no active drug.

After four weeks, the scientists observed remarkable signs of rejuvenation in the treated mice. Overall, the mice exhibited increased levels of telomerase and lengthened telomeres, biological changes indicative of cells returning to a growth state with reversal of tissue degeneration, and increase in size of the spleen, testes, and brain. “It was akin to a Ponce de León effect,” noted DePinho, referring to the Spanish explorer who sought the mythical Fountain of Youth.

“When we flipped the telomerase switch on and looked a month later, the brains had largely returned to normal,” said DePinho. More newborn nerve cells were observed, and the fatty myelin sheaths around nerve cells — which had become thinned in the aged animals — increased in diameter. In addition, the increase in telomerase revitalized slumbering brain stem cells so they could produce new neurons. To show that all this new activity actually caused functional improvements, the scientists tested the mice’s ability to avoid a certain area where they detected unpleasant odors that they associated with danger, such as scents of predators or rotten food. They had lost that survival skill as their olfactory nerve cells atrophied, but after the telomerase boost, those nerves regenerated and the mice regained their crucial sense of smell.

“One of the most amazing changes was in the animals’ testes, which were essentially barren as aging caused the death and elimination of sperm cells,” recounted DePinho. “When we restored telomerase, the testes produced new sperm cells, and the animals’ fecundity was improved — their mates gave birth to larger litters.” The telomerase boost also lengthened the rodents’ life spans compared to their untreated counterparts — but they did not live longer than normal mice, said the researchers.

The authors concluded, “This unprecedented reversal of age-related decline in the central nervous system and other organs vital to adult mammalian health justifies exploration of telomere rejuvenation strategies for age-associated diseases.” Other authors include members of the DePinho research group and Eleftheria Maratos-Flier, an HMS professor of medicine at Beth Israel Deaconess Medical Center.

The research was supported by grants from the National Institutes of Health and the Belfer Foundation.


Professor Vladimir Khavinson : January 2013.

Professor Vladimir Khavinson discovered, with its scientific team, the effects of the peptide together with the enzyme and different ways to synthesize it. He has conducted numerous scientific and clinical studies with this tetrapeptide in the past 15 years.

Extracts from press articles:

Live to 100 says Russian physician:

"The great secret of Khavinson for a more lasting existence is the action of peptides (biomolecules formed by connecting two or more amino acids by peptide bonds between an amine group of an amino acid, and a carboxyl group of another amino acid). The survey began 35 years ago at the Military Medical Academy in the former Soviet Union.

The graphics and data produced by the Russian in the Congress put an end to doubts. The results of tests performed with peptides by the doctor and his staff were all leaders, without exception. With success in experiments with rats, monkeys and humans, it was proved that peptides potentiate cell division, stimulate brain activity, promote the reduction of tumors and more.

"There isn't even the possibility of an allergic reaction," said the researcher.

"There is no stimulation or inhibition of processes, the peptides only regulate the body. They are natural substances, they do their work without disturbing the body. These bioregulators are absorbed by the body to repair only functions. There's no chance of overdose and toxicity. They act specifically on the target organ," he said, who also announced the soon release of a product line based on the new "heroes of longevity." The prognosis is that by 2020, the therapy can be practiced on a larger scale.

"More than 15 million people have been treated with these bioregulators, always showing 100% positive feedback. The protein synthesis is more powerful. A cell that normally divides 50 times has its capacity increased by almost 50% with peptides. In one test, the application of peptides in the elderly for 12 years brought declines in mortality and also restored the level of various hormones, such as melatonin - which reached levels only reported in human youth. There was also a great improvement in immunity, brain function and bone density, not to mention the reduction of respiratory diseases," Khavinson pointed out.

At the UN :

On October 1st, Khavinson presented his study to the world for the first time during the celebrations for the United Nations "Day of the Elderly" in the United Nations Palace in Geneva, Switzerland. At the time, ten countries invited him to work as a consultant in their respective ministries of health. "If it depended on me, the whole world would know about the barriers we are ready to surpass," said the scientist."

A Russian gerontologist is certain that the normal human life span is 120 years:

"April 3, 2012, Svetlana Smetanina. When Sophia Loren posed for a Pirelli calendar at 71 a few years ago, the remarkable actress must have had no idea that she was going to foment a revolution. She proved that you can look so good even in your seventies that they invite you to be a pin-up for a calendar that is famous for shooting only most stunning beauties. Russian gerontologist Vladimir Khavinson, who heads the International Association of Gerontology and Geriatrics, is certain that the normal life span of a human being is 110-120 years.

Vladimir Khavinson explains that all organs and tissues have reserve cells, or stem cells. That’s how nature arranged it – for injuries or some other needs. These are “spare parts.” After devastating diseases, such as strokes or heart attacks, your body has a chance to restore its capacity using the spares. These “reserve” cells make up about 30-40 percent of each organ. If all of them are used properly, a person lives to 100-110.

But the thing is that, for most people, these cells fail to work. They are not activated for various reasons – poor living conditions, bad environment, smoking and drinking. We waste the reserves that nature granted us to live longer. However, while we can give up smoking or alcohol, you can never get away from the stress and bad environment of a big city, if that is where you live."


Anti Ageing Conference, London 2012:

"Professor Khavinson is the President of the International Association of Gerontology and Geriatrics, European Region; Vice–President of the Gerontological Society of the Russian Academy of Sciences, Director of the Saint-Petersburg Institute of Bioregulation and Gerontology, Member of the Russian Academy of Medical Sciences, the main specialist in gerontology and geriatrics of the Health Committee and adviser of the Committee for Social Policy of the Government of St. Petersburg.



Since 1971 V. Khavinson has been engaged in studying of the role of peptides in regulation of the mechanisms of ageing, design, preclinical and clinical study of new peptide geroprotectors. His 35-year long investigations resulted in elaboration of a method for complex application of peptide bioregulators to slow down ageing and increase average life span. 6 peptide pharmaceuticals and 36 biologically active supplements developed by V. Khavinson have been introduced into clinical practice.

V. Khavinson is the author of over 700 publications, however, the major achievements are summarized in his books “Gerontological aspects of genome peptide regulation” (Karger AG, 2005) and “Peptides and Ageing” (NEL, 2002). He is the author of 189 Russian and International patents.

The treatment of elderly and senile persons with peptides improved physiological functions, and reduces the lethality by 44-49% over 15 years of clinical observation.

Thus, some interactions peptide-DNA epigenetically controlled genetic and cellular functions may be responsible for the recovery of homeostasis, and the extension of life. They seem to play an important role, even in the early stages of the origin of life and evolution."

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